I-Plone iwuhlelo lokuphatha okuqukethwe komthombo ovulekile noluvulekile (i-CMS) olwakhelwe phezu kweseva yohlelo lwe-Zope. I-Plone ibekwe njenge-CMS yebhizinisi futhi ivamise ukusetshenziselwa ama-intranethi nanjengengxenye yobukhona bewebhu bezinhlangano ezinkulu. Abasebenzisi bomkhakha womphakathi abasezingeni eliphezulu bahlanganisa i-U.S. Federal Bureau of Investigation, Uhulumeni wase-Brazilian, United Nations, City of Bern (Switzerland), New South Wales Government (Australia), kanye ne-European Environment Agency. Abasekeli bePlone bacaphuna irekhodi layo lokuphepha kanye nokufinyeleleka kwayo njengezizathu zokukhetha i-Plone.