I-GNU Guix System noma i-Guix System (ngaphambilini eyayaziwa ngokuthi i-GuixSD) iwukukhishwa okuphumayo, kwamahhala nokusatshalaliswa kwe-Linux komthombo ovulekile okwakhiwe eduze komphathi wephakheji we-GNU Guix. Inika amandla ukucushwa kwesistimu yokusebenza ememezelayo futhi ivumela ukuthuthukiswa kwesistimu umsebenzisi angakwazi ukuyibuyisela emuva. Isebenzisa i-GNU Shepherd init system kanye ne-Linux-libre kernel, ngokusekelwa kwe-GNU Hurd kernel esathuthukiswayo. NgoFebhuwari 3, 2015, iFree Software Foundation yengeze ukusatshalaliswa ohlwini lwayo lokusatshalaliswa kweLinux kwamahhala. Umphathi wephakeji le-Guix kanye ne-Guix System bathole ugqozi futhi base besekelwe kumphathi wephakheji le-Nix kanye ne-NixOS ngokulandelanayo.