GNU Guix System kapena Guix System (yomwe kale inali GuixSD) ndikutulutsa, kugawa kwaulere komanso kotseguka kwa Linux komwe kumamangidwa mozungulira woyang'anira phukusi la GNU Guix. Imathandizira kasinthidwe kachitidwe ka declarative ndikulola kukweza kwadongosolo komwe wosuta atha kubweza. Imagwiritsa ntchito GNU Shepherd init system ndi Linux-libre kernel, mothandizidwa ndi GNU Hurd kernel yomwe ikupangidwa. Pa February 3, 2015, Free Software Foundation inawonjezera kugawa pamndandanda wawo wovomerezeka waulere wa Linux. Woyang'anira phukusi la Guix ndi Guix System adalimbikitsidwa ndipo adatengera woyang'anira phukusi la Nix ndi NixOS motsatana.