Sistemụ GNU Guix ma ọ bụ Sistemụ Guix (nke bụbu GuixSD) bụ mwepụta na-atụgharị, nkesa Linux n'efu na mepere emepe wuru gburugburu GNU Guix njikwa ngwugwu. Ọ na-enyere nhazi sistemụ arụmọrụ nkwupụta ma na-enye ohere nkwalite sistemụ nke onye ọrụ nwere ike ịlaghachi azụ. Ọ na-eji sistemụ init GNU Shepherd yana Linux-libre kernel, yana nkwado nke kernel GNU Hurd n'okpuru mmepe. Na February 3, 2015, Free Software Foundation gbakwunyere nkesa na ndepụta nkesa Linux efu akwadoro. Onye njikwa ngwugwu Guix na Sistemụ Guix nwetara mmụọ nsọ ma dabere na njikwa ngwugwu Nix yana NixOS n'otu n'otu.