Tsarin GNU Guix ko Tsarin Guix (a da GuixSD) saki ne mai juyi, kyauta kuma buɗe tushen rarraba Linux wanda aka gina a kusa da manajan kunshin GNU Guix. Yana ba da damar saitin tsarin aiki na shela kuma yana ba da damar haɓaka tsarin wanda mai amfani zai iya juyawa. Yana amfani da GNU Shepherd init tsarin da Linux-libre kwaya, tare da goyon bayan GNU Hurd kwaya a karkashin ci gaba. A ranar 3 ga Fabrairu, 2015, Gidauniyar Software ta Kyauta ta ƙara rarrabawa zuwa jerin rabawa na Linux da aka amince da ita. Manajan kunshin Guix da Tsarin Guix sun zana wahayi daga kuma sun dogara ne akan mai sarrafa fakitin Nix da NixOS bi da bi.